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Indeed, we show only Aβ oligomers have a profound detergent effect in the membrane, causing widespread lipid extraction, see Bode/Viles et al 2019 [2]. The PhD student will build on these studies. Aims and Methodology: 1) Imaging the impact of Aβ (monomers; oligomers and fibrils) on membranes of various lipid compositions. Large unilamellar ...

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